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What filter does a Clean Comfort HE12M take?

It takes the AprilAire Water Panel 10 — OEM part number 10.

Clean Comfort HE12M, whole-house humidifier, whole house.

Lowest verified price: $15.98 — 1 panel, genuine AprilAire #10 at Home Depot. Home Depot shipping/pickup terms at checkout. Checked 2026-11-11.
Buy the 10 on Amazon — 10Direct link to the verified Amazon listing for this part. Amazon price is shown on Amazon; we do not quote it here.

The part, in brief

PartAprilAire Water Panel 10
Replacement intervalReplace at least once per heating season.
Per changeOne panel per change. Note: one Home Depot reviewer reports the panel runs short in the 500M despite the listing — check the model list on the box against your unit.
EquivalentsGeneralAire GA10

Verified prices

OptionPriceStore & shipping
Genuine (OEM)
1 panel, genuine AprilAire #10
$15.98Home Depot
Home Depot shipping/pickup terms at checkout · Checked 2026-11-11 · source
Genuine (OEM)
2-pack, genuine AprilAire #10 ($17.48 per panel)
$34.95DiscountFilters
Free shipping on orders $70+ at DiscountFilters; a fee applies below that · Checked 2026-11-11 · source
Genuine (OEM)
2-pack, genuine AprilAire #10
$19.00Home Depot
Home Depot shipping/pickup terms at checkout · Checked 2026-11-11 · source

Full record with every price, source and date: AprilAire Water Panel 10 page.